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For resistant isolates, alternative therapy is recommended.
Zidovudine: Fluconazole increases Cmax and AUC of zidovudine by 84% and 74%, respectively, due to an approximately 45% decrease in oral zidovudine clearance.
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In this nationwide cohort in Denmark, oral fluconazole use in pregnancy was associated with a significantly increased risk of spontaneous abortion.
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GVHD prophylaxis in allogeneic HSCT recipients conferred a sixfold-higher risk of infection than lower dosages ().
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Do not use this medication if you are allergic to fluconazole, or similar drugs such as clotrimazole (Lotrimin), econazole (Spectazole), ketoconazole (Nizoral), miconazole (Monistat), sertaconazole (Ertaczo), sulconazole (Exelderm), terconazole (Terazol), tioconazole (Vagistat-1), or voriconazole (Vfend).
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Another study at a 400 mg and 800 mg daily dose of fluconazole demonstrated that DIFLUCAN taken in doses of 400 mg per day or greater significantly increases plasma levels of terfenadine when taken concomitantly.
In each phase the subjects were given oral Fluconazole 400 mg and intravenous saline; oral placebo and intravenous Fluconazole 400 mg; and oral placebo and IV saline.
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Thus, the use of flucytosine without careful monitoring of serum drug levels is discouraged in this group of patients.
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Much of the variance in the rates of in vitro resistance can be explained by several factors: differences in the level of host immunosuppression, prior exposure to antifungal agents, the design of the study (longitudinal vs cross-sectional), the prevalence of non- albicans species of yeast, and differences in the in vitro methods used.
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