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How does memantine hydrochloride work? Glutamate can damage the nerve cells by excessively stimulating the NMDA receptors. Memantine works by blocking the NMDA receptors in the brain. This blocks the excessive activity of glutamate, but still allows the normal activation of these receptors that occurs when the brain forms a memory.
Can Alzheimer's start in your 30s? Alzheimer disease most commonly affects older adults, but it can also affect people in their 30s or 40s. When Alzheimer disease occurs in someone under age 65, it is known as early-onset (or younger-onset) Alzheimer disease. A very small number of people with Alzheimer disease have the early-onset form.
How do you treat agitation in dementia? The APA recommends benzodiazepines to treat prominent anxiety or infrequent agitation, preferably lorazepam and oxazepam rather than diazepam or clonazepam and suggests trazodone or SSRIs as alternative therapy for agitation in patients without psychosis or those who are intolerant to antipsychotics.
What are the benefits of taking donepezil? Donepezil benefits patients with moderate to severe Alzheimer's disease. A study of 295 patients with Alzheimer's disease has shown that the drug donepezil and memantine, already used in the mild to moderate stage of the illness, are also beneficial in its moderate to severe stage.
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