What does long term drug use do to the brain? The Affects Of Long Term Drug Use On The Brain. Drugs work by changing the brain's chemistry and by affecting the neuron signaling in many ways. The job of the neurons are to control cognition, muscle movement, sensory information and emotions. Does everyone gain weight on olanzapine? Atypical antipsychotics (AAPs) are effective for treating schizophrenia and have fewer side effects than typical antipsychotics, 6 but they can still cause extrapyramidal symptoms, 7 hyperprolactinemia, 8 sedation, 9 and weight gain. Previous studies have shown that it carries a lower risk of weight gain than olanzapine. Do antipsychotics cause negative symptoms? Negative Symptoms from Antipsychotic Medications. Both typical and atypical antipsychotic medications induced negative symptoms in healthy volunteers. With risperidone, but not with haloperidol, observer-rated negative symptoms increased significantly, independent of drowsiness.
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